Page 248 - Color Atlas of Biochemistry

Replication 239

A. Chromatin
Solenoid

Nuclear scaffold

Loops 200 nm
30 nm
DNA double helix Nucleosome

10 nm

Chromosome

2 nm
700 nm
Histone
1. Organization of chromatin molecules

DNA
N-terminal N-terminal
tail (H2B) tail (H3)
H2A

H2B

H3
Histone-Octamer
H4 (H2A · H2B)2(H3 · H4)2

2. Nucleosome

B. Histone
A Acetylation P Phosphorylation M Methylation

A P A A A A M

10
Animals S G R G K G G K G L G K G G A K R H R K V L R D N I
Plants S G R G K G G K G L G K G G A K R H R K V L R D N I
Yeast S G R G K G G K G L G K G G A K R H R K I L R D N I

30 40 50
Animals Q G I T K P A I R R L A R R G G V K R I S G L I Y E
Plants Q G I T K P A I R R L A R R G G V K R I S G L I Y E
Yeast Q G I T K P A I R R L A R R G G V K R I S G L I Y E

60 70
Animals E T R G V L K V F L E N V I R D A V T Y T E H A K R
Plants E T R G V L K I F L E N V I R D A V T Y T E H A R R
Yeast E V R A V L K S F L E S V I R D S V T Y T E H A K R
80 90 100
Animals K T V T A M D V V Y A L K R Q G R T L Y G F G G
Plants K T V T A M D V V Y A L K R Q G R T L Y G F G G
Yeast K T V T S L D V V Y A L K R Q G R T L Y G F G G

Amino acid sequence of histone H4

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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