Page 286 - Color Atlas of Biochemistry

Blood 277

A. Plasma proteins

Group Protein M in kDa Function
r
Albumins: Transthyretin 50-66 Transport of thyroxin and triiodothyronin
Albumin: 45 g · l -1 67 Maintenance of osmotic pressure; transport of
fatty acids, bilirubin, bile acids, steroid hor-
mones, pharmaceuticals and inorganic ions.

α -Globulins: Antitrypsin 51 Inhibition of trypsin and other proteases
1
Antichymotrypsin 58-68 Inhibition of chymotrypsin
Lipoprotein (HDL) 200-400 Transport of lipids
Prothrombin 72 Coagulation factor II, thrombin precursor
(3.4.21.5)
Transcortin 51 Transport of cortisol, corticosterone and
progesterone
Acid glycoprotein 44 Transport of progesterone
Thyroxin-binding globulin 54 Transport of iodothyronins
10 m
α -Globulins: Ceruloplasmin 135 Transport of copper ions
8
2
Antithrombin III 58 Inhibition of blood clotting
6
Haptoglobin 100 Binding of hemoglobin
4
Cholinesterase (3.1.1.8) ca. 350 Cleavage of choline esters
2
Plasminogen 90 Precursor of plasmin (3.4.21.7), breakdown
of blood clots
Macroglobulin 725 Binding of proteases, transport of zinc ions
Retinol-binding protein 21 Transport of vitamin A
Vitamin D-binding protein 52 Transport of calciols
β-Globulins: Lipoprotein (LDL) 2.000-4.500 Transport of lipids
Transferrin 80 Transport of iron ions
Fibrinogen 340 Coagulation factor I
Sex hormone-
binding globulin 65 Transport of testosterone and estradiol
Transcobalamin 38 Transport of vitamin B 12
C-reactive protein 110 Complement activation

γ-Globulins: IgG 150 Late antibodies
IgA 162 Mucosa-protecting antibodies
IgM 900 Early antibodies
IgD 172 B-lymphocyte receptors
IgE 196 Reagins

B. Electrophoresis

Buffer-saturated strip Cellulose-acetate sheet
of filter paper soaked with buffer + –
52-58%
Serum
+ sample –
Light absorption

Anode Cathode 2.4-4.4%
6.1-10.1%
Electro-
phoresis 8.5-14.5%
Staining Densitometry 10-21%

Cellulose-acetate sheet
Albumins α - α - β- γ-Globulins
2
1

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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