Page 364 - Color Atlas of Biochemistry

Brain and sensory organs 355

A. Receptors for neurotransmitters

Ionotropic Metabotropic
Receptor Transmitter Ion(s) Effect Receptor Transmitter Effect
Acetyl- Acetyl- Acetylcholine Acetylcholine [ Ca 2 ]
choline choline Na (muscarinic)
(nicotinic) M1, M3, M5, M2, M4 [cAMP]

5HT3 Serotonin 5HT 1 Serotonin [ Ca 2 ]
Na
5HT 2 „ [cAMP]
5HT 4 „ [cAMP]
GABAa GABA CI α 1 [ 2 ]
Norepinephrine Ca
α 2 „ [cAMP]
„
β 1 , β 2 , β 3 [cAMP]
Glycine Glycine CI
D 1 , D 5 Dopamine [cAMP]
AMPA Glutamate Na K D 2 , D 3 , D 4 „ [cAMP]
NMDA Glutamate Na K Ca 2
Kainate Glutamate
Na K δ,κ,µ Opioids [cAMP]

B. Acetylcholine receptors
Acetylcholine Na Effector enzyme
Receptor G protein PL-C
α γ α β Adenylate cyclase

GTP
1. Nicotinic receptor 2. Muscarinic receptors

C. Metabolism of acetylcholine
S
A
Acetyl- S 1 Acetylcholine 1 Choline acetyltransferase
A
A 2.3.1.6
P
2 Acetylcholinesterase
Choline Packing
P P 3.1.1.7
3 3 Acetate-CoA ligase
6.2.1.1
A S
PP P A Ca 2
Acetate Synaptic Storage
vesicle

Re-uptake Release
Presynaptic membrane
Choline H O
2

Acetate 2 Acetylcholine

Synaptic
cleft
Curare
Neurotoxins Receptor

Postsynaptic membrane

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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