Page 84 - Color Atlas of Biochemistry
P. 84
Peptides and Proteins 75
A. Folding and denaturation of ribonuclease A
N terminus
N terminus
58-110
26-84
His -12
40-95
26 His -12
65-72
Lys-41 His-119
C terminus
40
Lys-41
Folding
Denaturation
58
65
B. Energetics of protein folding
+
72 Increased order
in the molecule
Interactions
in the
-T·∆S conf molecule
Reduced
order
in water
Energy
84
∆H falt -T·∆S was
95
Free enthalpy
of folding
– (∆Gfold)
110
His-119
C terminus ∆Gfold = ∆Hfold –T·∆Swater –T·∆Sconf
Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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