Page 86 - Color Atlas of Biochemistry

Peptides and Proteins 77

A. Structure of insulin

C Peptide OOC
30 29 28 27 26 25 24 23
22
E R R A K P T Y F F G
R
B chain
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
E
F V N Q H L C G S H L V E A L Y L V C G
21
NH 3
Q 1 2 3 4 5 6 7 11 12 13 14 15 16 17 18 19 20 21
K R G I V E Q C S L Y Q L E N Y C N A chain
C C
NH 3 T S I OOC
1. Primary structure Disulfide bonds
8 9 10
A chain

NH 3
OOC

NH 3

C peptide

OOC
B chain

2. Secondary and tertiary structure 3. Quaternary structure
B. Insulin (monomer)

A-chain

B-chain

Invariant
residue

1. 2.

Apolar
side chain
Involved
in subunit
interactions

Polar
side chain 3.

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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