Page 94 - Color Atlas of Biochemistry
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Nucleic Acids        85


                  A. DNA: structure

                                                                              5'                  3'
                                       H
                                 H
                                        N
                                  C         H                 O   P  O
                            H        C         O                             3.4 nm
                     O         C   C  N         C      N         O
                                N         H         C    C   H
                                    C        N   G                CH
                                                    C N       O     2                  C   G
                                    O         C
                        O               H  N      N                                      A    T
                  H C
                    2
                                            H
                     O
                                        H                        O
                 O   P  O                    H   O       CH
                           H      N       N                3  O  P  O      0.34 nm
                     O         C                   C   C
                                     C  C                        O
                               N   C  A   N   H  N    T  C  H    CH
                                     N   C          C  N     O      2
                        O                         O
                  H C                     H
                   2
                                                                          Minor                 Major
                     O                     OH      CH OH                  groove                groove
                                                     2
                                                O               O
                 O   P  O
                                 2'-deoxy-    H   H
                                 D-ribose
                                            H  2    H                        5'                    3'
                                              H  OH
                 1. Formula                                                  2. Double strand

                  B. Coding of genetic information

                                                                                                     C
                                    3'            5'             3'                             3'
                                                                                               C
                                                          Codon
                                                          (triplet)                             T    Phe
                                                                                                T

                  Sense strand                                                                 C
                  (+) strand,                                                                  A     Tyr
                  “coding strand”                                                               T
                                                                                                T
                                                                                               C     Ala
                                                                                               G
                                                                                                T
                                                                                               C     Thr
                                                                                               A
                                                                                               A
                   Template                                                                    A     Glu
                   strand                                                                      G
                   (–) strand,                                                                 A
                  “codogenic                                                                   A
                   strand”                                                                           Glu
                                                                                               G
                                                                                               G
                                                                                                T    Met
                                                                                               A
                                                                                                5'   N

                                           1.                       2.                         3.



           Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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