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98     CHAPTER 6  Retinal vascular analysis: Segmentation, tracing, and beyond




                         2  Benchmark datasets and evaluation metrics

                         2.1  Datasets
                         Table 1 provides a summary of 12 representative retinal imaging benchmark datasets.
                         As some URLs of these published datasets are relocated over the years, we strived to
                         identify the current web addresses.
                                  1
                                                   2
                            DRIVE  [24] and STARE  [25] are two popular benchmarks for vessel
                         segmentation. DRIVE contains 40 fundus images of size 768 × 584, obtained using
                         Canon CR5 nonmydriatic 3CCD camera with field of view (FOV) of 45 degrees.
                         STARE involves 20 fundus images of size 605 × 700 taken from a TopCon TRV-50
                         fundus camera at 35-degree FOV. Apart from segmented vessel masks, the artery/
                                                                    3
                         vein vessel annotations are further labeled by RITE  [26, 27] for DRIVE dataset.
                         Azzopardi and Petkov [28] provided vessel junction annotations, including vascular
                         bifurcations and crossovers.
                                4
                            HRF  [29] consists of 45 images, of which one-third are images from healthy
                         patients, one-third are patients with diabetic retinopathy (DR), and the rest are
                         images of glaucomatous patients. Binary gold standard vessel segmentation images,
                         generated by a group of experts, are available for each image. The size of fundus
                         images is 3504 × 2336.
                                      5
                            CHASEDB1  [30] includes 28 retinal fundus scans from 14 children. Images
                         were recorded using a Nidek NM-200-D fundus camera with a 30-degree FOV, with
                         a resolution of 999 × 960 pixels. Two experts’ segmentations are available for each
                         images as ground truth.
                                 6
                            ARIA  [31] consists of 143 images taken from either healthy subjects, diabetics,
                         or patients with age-related macular degeneration (AMD). Obtained with a Zeiss
                         FF450+ fundus camera with a 50-degree FOV. In addition to vessel segmentation,
                         annotations of the OD and fovea are also provided.
                                         7
                            The DR HAGIS  [32] dataset is composed of 40 fundus images, which were
                         acquired in different screening centers in the United Kingdom for DR screening
                         purpose, using a Topcon TRC-NW6s, a Topcon TRC-NW8, or a Canon CR DGi
                         fundus camera with a horizontal 45-degree FOV. The resulting images are of different
                         sizes, being either 4752 × 3168, 3456 × 2304, 3126 × 2136, 2896 × 1944, or 2816
                         × 1880 pixels. The dataset is divided into four comorbidity subgroups, that is, DR,
                         hypertension, AMD, and glaucoma. Each subgroup comprises 10 images, with the
                         image of only one patient being duplicated into two subgroups. Vessel segmentation
                         annotation is also provided for each image.


                         1  See http://www.isi.uu.nl/Research/Databases/DRIVE/.
                         2  See http://www.ces.clemson.edu/~ahoover/stare/.
                         3  See https://medicine.uiowa.edu/eye/rite-dataset.
                         4  See https://www5.cs.fau.de/research/data/fundus-images/.
                         5  See https://blogs.kingston.ac.uk/retinal/chasedb1/.
                         6  See https://eyecharity.weebly.com/aria_online.html.
                         7  See https://personalpages.manchester.ac.uk/staff/niall.p.mcloughlin/.
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