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 Encyclopedia of Physical Science and Technology  EN014J-683  July 30, 2001  20:3







              Separation and Purification of Biochemicals                                                  673

              as impetus to design so-called high performance chro-  TURE • MASS TRANSFER AND DIFFUSION • MEMBRANES,
              matographic disks (or monoliths), which are true high  SYNTHETIC,APPLICATIONS • PHARMACEUTICALS • PRO-
              performance stationary phases for biochromatography.  TEIN SYNTHESIS
              They typically consists of a rigid porous polymer (thick-
              ness millimeter range, diameter centimeter range) with a  BIBLIOGRAPHY
              well-defined, narrow pore size distribution. The disks are
              prepared by in situ polymerization of suitable monomers
                                                                Deutscher, M. P., ed. (1990). “Methods in Enzymology, Volume
              and functionalized later. Examples of materials include
                                                                 182, Guide to Protein Purification,” Academic Press, San Diego,
              rigid poly(glycidyl methacrylate-co-ethylene dimethy-  CA.
              lacrylate) (EDMA-GMA) networks, poly(styrene-co-  Heftmann, E., ed. (1992). “Chromatography 5th Edition: Fundamen-
              divinylbenzene) copolymers, and silica phases obtained  tals and Applications of Chromatography and Related Differential
              by a variant of the sol–gel technique.             Migration Methods,” Journal of Chromatography Library, Volumes
                                                                 51A–51B, Elsevier, Amsterdam.
                                                                Kastner, M., ed. (2000). “Protein Liquid Chromatography,” Journal of
                                                                 Chromatography Library, Volume 61, Elsevier, Amsterdam.
              SEE ALSO THE FOLLOWING ARTICLES                   Sofer, G., and Itagel, L. (1997). “Handbook of Process Chromatography:
                                                                 A Guide to Optimization, Scale-Up, and Validation,” Academic Press,
              BIOMATERIALS,SYNTHESIS,FABRICATION, AND APPLI-     San Diego, CA.
                                                                Subramanian, G., ed. (1995). “Process Scale Liquid Chromatography,”
              CATIONS • BIOPOLYMERS • BIOREACTORS • ELEC-
                                                                 VCH, Weinheim.
              TROPHORESIS • INCLUSION (CLATHRATE)COMPOUNDS •    Subramanian, G., ed. (1998). “Bioseparation and Bioprocessing—A
              LIQUID CHROMATOGRAPHY • MAMMALIAN CELL CUL-        Handbook,” Vol. 1, Wiley—VCH, Weinheim.
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