Page 415 - Fundamentals of Air Pollution 3E

TABLE 22-2a
Summary of Lowest Observed Effect Levels for Key Lead-Induced Health Effects in Adults
Lowest observed
effect level (PbB)" Heme synthesis and Neurological Effects on Reproductive Cardiovascular
(/*g/dl) hematological effects effects the kidney function effects effects
100-120 Encephalopathic signs Chronic nephropathy
and symptoms
80 Frank anemia )
60 1 Female reproductive
1 effect s
50 Reduced hemoglobin Overt Altered testicular
production subencephalopathic function
neurological
symptoms
\ I , ,
40 Increased urinary ALA Peripheral nerve
and elevated dysfunction (slowed
coproporphyrins nerve conduction)
30 Elevated blood pressure
(white males, aged
40-59)
25-30 Erythroeyte
protoporphyrin (EP)
elevation in males
15-20 Erythroeyte
protoporphyrin (EP)
elevation in females
<10 ALA-D inhibition ?
" PbB = blood lead concentrations.
Source: U.S. Environmental Protection Agency, Air Quality Criteria for Lead, EPA-600-8-83/028aF, June 1986.