Page 268 - Industrial Ventilation Design Guidebook

REFERENCES 229

17 77
removed by the mucociliary escalator (mucociliary clearance). ' Deposi-
tion and adherence of particulates onto airway mucus also prevents aspi-
77 119
'
rated pollutants, 108 118 viral particles, ' and infected epithelial cells shed
17 22 119
77
from the airway wall from reaching the alveoli. ' ' Airway mucus also
plays an important role in buffering and chemically neutralizing inhaled pol-
lutant gases. 120 In addition, mucus serves to protect the airway epithelium
against injury caused by rapid fluctuations in airstream temperature, T,, and
humidity, C a. 66
Disruption of these defense mechanisms can lead to bacterial colonization
or viral infection. Mucus temperature is important in controlling respiratory
infections because decreasing T m below central body core temperature not
73 76
only impairs ciliary movement, ' but also enhances viral replication, 21
greatly increasing the likelihood of respiratory infection. Drying of airway
mucus also increases the possibility of respiratory infection by reducing mucus
'
thickness and impairing mucociliary clearance. 121 122

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