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500   Industrial Wastewater Treatment, Recycling, and Reuse


          13.5 CASE STUDIES

          In this section we present three case studies related to important sections of
          the chemical industry responsible for major environmental pollution: the
          chemical, fertilizer, textile, and bulk drug industries.

          13.5.1 Case Study 1: Pharmaceutical API (Active
          Pharmaceutical Ingredient) Industry
          The pharmaceutical API (active pharmaceutical ingredient) industry, which
          is also known as the bulk drug industry, manufactures drug intermediates
          and end-products. In the majority of cases, API industries are involved in
          contract manufacturing, meaning that their products are manufactured
          according to client requirements.
             API industries manufacture multiple products, and the characteristics of
          these products differ in terms of quality and quantity. Thus, effluents from
          the industries vary in composition, and hence, the parameters associated
          with the effluents also vary.

          13.5.1.1 Effluent from the API Industry:
          The types of effluents produced by API industries are listed below, along with
          the manufacturing activities or other sources that produce those effluents.
          1. Lean stream (low COD–low TDS effluents)
             a. Process
                i. Reactor washings from the second wash onwards
             b. Utility
                  i. DM plant regeneration waste
                 ii. RO (reverse osmosis) reject stream
                iii. Cooling tower blow down
                iv. Boiler blow down
             c. Other
                 i. Floor washings
                ii. Various drains.
          2. ML stream (high COD–high TDS effluent)
             a. Product separation
             b. First washings of reactor
             c. Traces of solvents from plant.

          13.5.1.2 Lean Stream
          The lean stream results from the majority of washings and utility waste, and
          as a result, it has moderate concentrations of COD and TDS, which are trea-
          ted using physico-chemical and biological methods.
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