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                                                            Chapter 11: Getting a Little Interaction with Two-Way ANOVA
                                                    Factor B is significant but not factor A
                                                    Figure 11-1c shows where factor B is significant but A isn’t. The lines are flat
                                                    across dosage levels indicating that dosage has no effect on blood pressure.
                                                    However, the two lines for times per day are spread apart, so their effect on
                                                    blood pressure is significant. Parallel lines mean no interaction effect.
                                                    Neither factor is significant
                                                    Figure 11-1d shows two flat lines that are very close to each other. By the
                                                    previous discussions about Figures 11-1b and 11-1c, you can guess that this
                                                    figure represents the case where neither factor A nor factor B are significant,
                                                    and you don’t have an interaction effect because the lines are parallel.
                                                    Interaction term is significant
                                                    Finally you get to Figure 11-1e, the most interesting interaction plot of all. The
                                                    big picture is that because the two lines cross, then factors A and B interact
                                                    with each other in the way that they operate on the response. If they didn’t
                                                    interact, then the lines would be parallel.                           191
                                                    Start with the top line of Figure 11-1e. When you take the drug two times per
                                                    day at the low dose, you get a low change in blood pressure; as you increase
                                                    dosage, blood pressure increases also. But when you take the drug once per
                                                    day, the opposite result happens.
                                                    If you didn’t look for a possible interaction effect before you examined the main
                                                    effects, you may have thought no matter how many times you take this drug
                                                    per day, the effects will be the same. Not so! Always check out the interaction
                                                    term first in any two-way ANOVA. If the interaction term is significant, you have
                                                    no way to pull out the effects due to just factor A or just factor B; they’re moot.
                                                    Checking the main effects of factor A or B without checking out the interaction
                                                    AB term is considered a no-no in the two-way ANOVA world. Another taboo is
                                                    examining the factors individually (also known as the main effect) if the inter-
                                                    action term is significant.
                                         Testing the Terms in Two-Way ANOVA
                                                    In a one-way ANOVA, you have only one hypothesis test. You use an F-test
                                                    to determine whether the means of the y values are the same or different as
                                                    you go across the levels of the one factor. In two-way ANOVA you have more
                                                    items to test besides the overall model. You have the interaction term AB
                                                    and possibly the main effects of A and B. Each test in a two-way ANOVA is an
                                                    F-test based on the ideas of one-way ANOVA (see Chapter 9 for more on this).
                                                    First, you test whether the interaction term AB is significant. To do this, you
                                                    use the test statistic F =  MS AB  , which has an F-distribution with (i – 1)  ( j – 1)
                                                                                                               *
                                                                         MSE
                                                    degrees of freedom from MS AB (mean sum of squares for the interaction term
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