Page 260 - Multidimensional Chromatography

Biomedical and Pharmaceutical Applications 255

Reference 28 28 22 23 37 24 32 29 66 69 69 39 34 38 34 31

Detection c post-Flu post-Flu UV MS–MS UV UV UV UV EC UV UV UV UV UV UV UV

Subsequent LC mode(s) b C18 C18 C18 C18 C18 CIEX C18 silica; CN C18 C18 C18 C18 C18; C18 C18 C18; C18 silica; silica
Biomedical applications of on-line heart-cut LC–LC

First LC mode b C18 C18 C18 C18 ion-pair C18 C8 PRP phenyl CIEX C18 C18 C18 ion-pair C18 ion-pair C18 C18 phenyl

Sample preparation a deproteination buffer dilution none none liq–liq extraction ultrafiltration liq–liq extraction liq–liq extraction deproteination SPE dilution SPE liq–liq extraction liq–liq extraction liq–liq extraction liq–liq extraction

Table 11.1

Sample matrix human plasma human urine human/bovine urine bovine urine human serum human plasma pig tissue bovine tissue human/rat plasma human plasma human urine human plasma human serum human serum human serum tissue bovine

Drugs and Related Compounds

Analyte(s) Ampicillin -agonists Basic drugs Bupivacaine Chloramphenicol Dexamethasone Dopa and its metabolite Efletirizine Glycyrrhizin and its metabolite Ibuprofen Manidipine and its metabolite Mefenamic acid Melengestrol acetate