Page 263 - Multidimensional Chromatography

258 Multidimensional Chromatography

Reference 54 46 48 51 54 57 50 58 11 59 68 60 62 61 67

c
Detection UV UV UV EC EC EC or MS UV UV UV EC EC UV Flu UV Flu

b
Subsequent LC mode(s) C18; C18 C18 with L-prolinamide Chiralcel OD -CD C18 C18; C18 -CD Ovomucoid CIEX SEC; CIEX; C8 or C18 C18 C18 affinity ion-pair C18 AIEX C18

b
(continued) First LC mode BSA-silica C18 silica phenyl AGP phenyl C18 SEC affinity PRP CIEX SEC C18 SEC PRP

Table 11.1 Sample a preparation SPE liq–liq extraction liq–liq extraction SPE SPE SPE liq–liq extraction dilution buffer homogenization, centrifugation SPE centrifugation on-line SPE none centrifugation sulfitolysis deproteination

Sample matrix human plasma rat liver microsomes human plasma human plasma human plasma human plasma human plasma human serum urine cytosol of human lung tissue human urine blood rabbit bovine serum human serum cells E. coli human blood/plasma

Analyte(s) Oxazepam d p-HPPH Pimobendan and its metabolite Terbutaline Verapamil and its metabolites Endogenous Compounds Creatinine Glutathione S-transferases Hydroxy- deoxyguanosine Hydroxytryptamine and its metabolite Immunoglobulin G and its multimers Neopterin Proinsulin fusion protein Riboflavin