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374    7. Point Estimation

                                 7.5.3   A Generalization of the Cramér-Rao Inequality
                                 In the statement of the Cramér-Rao inequality, Theorem 7.5.1, the random
                                 variables X , ..., X  do not necessarily have to be iid. The inequality holds with
                                          1
                                                n
                                 minor modifications even if the X’s are not identically distributed but they are
                                 independent.
                                 Let us suppose that we have iid real valued observable random variables X ,
                                                                                                j1
                                 ..., X , from a population with the common pmf or pdf f (x; θ) where X ’s and
                                                                                            j
                                     jn
                                                                                j
                                 X ’s are independent for all j ≠ l = 1, ..., k, x ∈  χ ⊆  ℜ. Here, we have the
                                  l
                                 unknown parameter θ ∈ Θ  ⊆  ℜ. We denote X = (X , ..., X , ..., X , ..., X )
                                                                                  1n1
                                                                                         k1
                                                                            11
                                                                                               knk
                                 and X = (x , ..., x , ..., x , ..., x ) with             x ∈  . Let
                                                                                            χ n
                                          11    1n1    k1    knk
                                 us pretend that we are working with the pdf’s and hence the expectations of
                                 functions of the random variables would be written as appropriate multiple
                                 integrals. In the case of discrete random variables, one will replace the inte-
                                 grals by the corresponding finite or infinite sums, as the case may be. Let us
                                 denote the information content of X  by I  (θ) which is calculated as E
                                                                 j1   X3                         ?
                                 [( [logf (X;θ)]) ]. We now state a generalized version of the Theorem 7.5.1.
                                              2
                                        j
                                 Its proof is left as Exercise 7.5.16.
                                                                                     χ
                                    Standing Assumptions: Let us assume that the support   does not in-
                                 volve θ and the first partial derivative of f (x;θ), j = 1, ..., k with respect to θ
                                                                     j
                                 and the integrals with respect to X are interchangeable.
                                    Theorem 7.5.4 Suppose that T = T(X) is an unbiased estimator of a real
                                 valued parametric function T(θ), that is E (T) = T(θ) for all θ ∈ Θ. Assume
                                                                     θ
                                 also that   T (θ), denoted by T′(θ), exists and is finite for all θ ∈ Θ. Then, for
                                 all θ ∈ Θ, under the standing assumptions we have:
                                 The expression on the rhs of the inequality in (7.5.18) is called the Cramér-
                                 Rao lower bound (CRLB) as before.
                                    Example 7.5.13 Let X , ..., X  be iid Exponential(θ) so that their common
                                                            1n1
                                                      11
                                                      -1 -x/θ
                                 pdf is given by f (x;θ) = θ e  with the unknown parameter θ ∈ Θ = (0, ∞) and
                                              1
                                 χ  = (0, ∞). Also, suppose that X , ..., X  are iid Gamma(α, θ), that is, their
                                                                   2n2
                                                            21
                                                                      -1 -x/θ α-1
                                 common pdf is given by f (x; θ) = {θ Γ(α)} e x  with the same unknown
                                                                 α
                                                       2
                                               χ
                                 parameter θ and   = (0, ∞), but α(> 0) is assumed known. Let us assume that
                                 the X ’s are independent of the X ’s. In an experiment on reliability and survival
                                                            2
                                     1
                                 analyses, one may have a situation like this where a combination of two or more
                                 statistical models, depending on the same unknown parameter θ, may be ap-
                                 propriate. By direct calculations we obtain I (θ) = θ  and I (θ) = αθ . That
                                                                             -2
                                                                                            -2
                                                                      X1           X2
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