Page 515 - Tandem Techniques
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electrospray probe was about 8 cm. The background spectra from the atmospheric ionization interface
were very simple, in which the protonated methanol peak (m/z = 33) was dominant. However, spectra
from the electrospray interface also exhibited a strong background of sodium ions.
Figure 13.13
The Capillary Electrophoresis/API-MS Tandem Apparatus.
Capillary Electrochromatography Employing the Electrospray Interface
Electrochromatography is not a form of electrophoresis, and so strictly, the subject should not be
included in a chapter on electrophoresis tandem systems. Electrochromatography is a term given to a
liquid chromatographic separation that employs a capillary column, but utilizes electroosmotic flow to
drive the mobile phase through the column. Physically, the system is very similar to capillary
electrophoresis, and employs a very comparable type of apparatus. Consequently, the
electrochromatograph /mass spectrometer tandem system will be included in this chapter.
The use of electro-osmotic flow, to replace the high-pressure pump in a liquid chromatograph, not only
simplifies the mobile phase supply system,
