Page 53 - Visions of the Future Chemistry and Life Science

42 M. J. SUTCLIFFE AND N. S. SCRUTTON

primarily on static pictures of enzymes and enzyme-ligand complexes. As
we start the new millennium, our quest for a better understanding will be
driven by an appreciation of a role for protein dynamics – both experimen-
tal and computational – in driving enzyme-catalysed reactions. The future
will thus witness a flurry of activity directed at understanding the role of
quantum mechanics and protein motion in enzyme action.

2.11 Further reading

Bendall, D. S. (ed.) 1996 Protein electron transfer. Oxford: Bios Scientific
Publishers.
Fersht, A. 1985 Enzyme structure and mechanism. New York: W. H.
Freeman.
Kohen, A. & Klinman, J. 1999 Hydrogen tunneling in biology. Chem. Biol. 6,
R191–R198.
Scrutton, N. S., Basran, J. & Sutcliffe, M. J. 1999 New insights into enzyme
catalysis: ground state tunnelling driven by protein dynamics. Eur. J.
Biochem. 264, 666–671.
Sutcliffe, M. J. & Scrutton, N. S. 2000 Enzymology takes a quantum leap
forward. Phil. Trans. R. Soc. Lond. A 358, 367–386.