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100    CHAPTER 3  The Laplace Transform

                                 Then
                                                                   F(s) − f (0)M(s)
                                                            R(s) =               .
                                                                       sM(s)
                                 If we can invert R(s),wehave r(t).
                                    We will see how this model works in a specific example. Suppose we want to have f (t) =
                                 A + Bt doses of a drug on hand at time t with A and B as positive constants. Thus, f (0) = A,

                                 and the need increases in time at the rate f (t) = B. Suppose the mortality function is
                                                               m(t) = 1 − H(t − k)

                                 in which H is the Heaviside function and k is a positive constant determined by how long doses
                                 remain effective.
                                    Now
                                                              A   B           1   1
                                                       F(s) =  +    and M(s) =  − e  −ks .
                                                              s   s 2         s   s
                                 The transform of the replacement function is
                                                              F(s) − F(0)M(s)
                                                        R(s) =
                                                                   sM(s)
                                                              A  +  B     1  − e
                                                                            1 −ks
                                                               s  s 2 − A  s  s
                                                            =
                                                                        1 −ks
                                                                  s  1  − e
                                                                    s   s
                                                              A    1     B    1     A
                                                            =          +          −
                                                                          2
                                                              s 1 − e −ks  s 1 − e −ks  s
                                 in which we have omitted some routine algebra in going from the second line to the third. Now
                                 0 < e  −ks  < 1for ks > 0, so we can use the geometric series to write
                                                                  ∞            ∞
                                                           1
                                                               =    (e  −ks n     e −kns .
                                                                       ) = 1 +
                                                        1 − e −ks
                                                                 n=0           n=1
                                 Therefore,

                                                                      ∞
                                                                  1      1
                                                         R(s) = A   +     e −kns
                                                                  s      s
                                                                      n=1

                                                                       ∞
                                                                  1       1        A
                                                             + B    +      e −kns  −  .
                                                                  s  2   s  2      s
                                                                      n=1
                                 Invert this term by term to obtain
                                                        ∞                   ∞

                                             r(t) = A + A  H(t − nk) + Bt + B  (t − nk)H(t − nk) − A
                                                        n=1                 n=1
                                                       ∞

                                                = Bt +   (A + B(t − nk))H(t − nk).
                                                       n=1
                                 Notice that t − nk < 0 (hence H(t − nk) = 0) if t/n < k. Since k is given and n increases from 1
                                 through the positive integers, this always occurs after some time, so “most” of the terms of this
                                 series vanish for a given time.




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                                   October 14, 2010  14:14  THM/NEIL    Page-100        27410_03_ch03_p77-120
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