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258 13. MULTIDIMENSIONAL BIOMECHANICS APPROACHES
TABLE 13.1 Cells, Applied Stimuli (Electrical and/or Mechanical) and Material Used for Specific Representative Biomedical
Applications—cont’d
Stimuli
Tissue Cells Electric Mechanical Material Reference
Rat neuronal 100mV (DC)200 PPy film [85]
phaeochromocytoma (PC12)
PC12 10mVcm 1 Poly(lactic-co-glycolic acid) (PLGA) films [89]
coated with PPy
PC12 0, 2, 8 and 20μA/ PDLLA/CL membrane coated with PPy [90]
mm (DC)
Dorsal root ganglia (DRG) 10V (DC) PCL/PPy nanofibers [91]
Cochlear neural explants Biphasic pulses, PPy film [92]
100μs,
2
1mA/cm ,
250Hz
PC12 0.1V, 1Hz Copolymer of hydroxyl-capped [93]
poly(L-lactide) (PLA) and carboxyl-capped
aniline pentamer (AP) film
Schwann cells 100mV (DC) PPy/chitosan membrane [94]
Human umbilical cord 100mV/mm (DC) PPy/PLA nanofibers [95]
mesenchymal stem cells
(huMSCs)
Mousse neuroblastoma cells 2–3mV, 1200Hz Poled PVDF fibers [11]
(Nb2a)
PC12 40mV PLA/PPy fibers [96]
PC12 100 mV PPy films [97]
PC12 10mV/cm PPy-PLGA electrospun meshes [98]
PC12 Ultrasound stimulation, 20W, Stable glycol-chitosan-boron nitride [99]
40kHz nanotubes (BNNT)
Exogenous human neural +1V to 1V PPy scaffold [100]
progenitor cells square wave
1kHz
Rat spinal cord neurons Vibration base, 50Hz PVDF film [101]
SH-SY5Y neuron-like cells Ultrasounds, 0.1, 0.2, 0.4 and Barium titanate nanoparticles [102]
0.8W/cm 2
SH-SY5Y neuron-like cells Ultrasounds, PVDF-TrFE/barium titanate film [103]
5s twice a day
Bone Rat bone marrow-derived 0.2, 0.4, and 0.7V/ 3-D collagen fibers [104]
mesenchymal stem cells min
(MSCs) for 60min
Human adipose stem cells 1Hz with maximum β-PVDF “poled +” film [43]
(hASCs) amplitude of 1mm
MC3T3-E1 preosteoblasts Frequency of 1Hz β-PVDF “poled ” film [41]
Osteoblasts 10mA, 10Hz (AC) PLLA/carbon nanotube (CNT) nonporous [105]
for 6h/day substrates
Osteoblasts 100μA (DC) PLA/CNTs nanofiber [106]
Goat marrow stromal cells A lab rotator (model DSR β-PVDF film [107]
(GMCs) 2800V, Digisystem
Laboratory Instruments)
II. MECHANOBIOLOGY AND TISSUE REGENERATION