Page 336 - Advances in Biomechanics and Tissue Regeneration

334 16. ON THE SIMULATION OF ORGAN-ON-CHIP CELL PROCESSES

x10 6 x10 6
18 18
S: Alive S: Alive
16 S: Dead 16 S: Dead
EXp: Alive Experimental
14
Cell concentration [c/mL] 12 8 Cell concentration [c/mL] 14 8
12
10
10

4 6 6 4
2 2
0 0
0 0.05 0.1 0.15 0.2 0.25 0 0.05 0.1 0.15 0.2 0.25
(A) Length [mm]
(B) Length [mm]
x10 6 x10 6
18 18
S: Alive S: Alive
16 S: Dead 16 S: Dead
Experimental 14 Experimental
14
Cell concentration [c/mL] 12 8 Cell concentration [c/mL] 12 8
10
10

4 6 6 4
2 2
0 0
0 0.05 0.1 0.15 0.2 0.25 0 0.05 0.1 0.15 0.2 0.25
(C) Length [mm] (D) Length [mm]
x10 6
18
S: Alive
16 S: Dead
Experimental
14
Cell concentration [c/mL] 12 8
10

4 6
2
0 0 0.05 0.1 0.15 0.2 0.25
(E) Length [mm]
FIG. 16.6 Evolution of simulated and measured profiles over time. (A) Cell culture at the beginning of the experiment. (B) Cell culture at 7 days.
(C) Cell culture at 11 days. (D) Cell culture at 17 days. (E) Cell culture at 21 days.

FIG. 16.7 Evolution of cell culture for the experimental and computational results.

II. MECHANOBIOLOGY AND TISSUE REGENERATION