Page 391 - Advances in Biomechanics and Tissue Regeneration

388 19. IMPACT OF MECHANOBIOLOGICAL PERTURBATION IN CARTILAGE TISSUE ENGINEERING

environment. Computational modeling has also been utilized to provide predictive evaluation to investigate the com-
plex relationships between external mechanical forces, the cell, and the surrounding substrate [59, 151–154]. Further
research is needed to fully elucidate how chondrocytes and MSCs sense and respond to the complex sets of mechanical
stimuli applied in tandem. It should also be recognized that the creation of a translational platform to encompass all the
relevant biological, biochemical, and mechanical cues could present a significant technical challenge. Thus the onus
will be on the identification of the vital elements from the vast scientific landscape for the optimal application to car-
tilage tissue engineering and regeneration.

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II. MECHANOBIOLOGY AND TISSUE REGENERATION