Page 87 - Advances in Forensic Applications of Mass Spectrometry - Jehuda Yinon

1522_C02.fm Page 74 Wednesday, November 12, 2003 9:36 AM

Ref. 20 21 40 41 39 22 23 62 52 57
42
44
43
LOD (mg/l) 0.5–1.0 0.5–10 10.0 0.3–2.5 0.1–10 0.5–5.0 1.0–5.0 0.25–0.5 0.05 0.1 2–5 0.1 25.0
m m m

Detection ESI-QQQ, MRM ESI-QQQ, MRM ESI-Q, SIM ESI-QQQ, MRM APCI-Q, SIM ESI-Q, SIM ESI-QQQ, MRM ESI-QQQ, MRM ESI-QQQ, MRM ESI-QQQ, MRM ESI-QQQ, MRM ESI-QQQ, MRM ESI-Q, SIM

Column, Elution Conditions Silica, ACN-HCOOH isocr. Silica, ACN-TFA isocr. C8, ACN-HCOONH 4 isocr. C18, ACN-HCOOH grad. C18, ACN-HCOONH 4 isocr. C18, ACN-HCOONH 4 grad. C18, ACN-HCOONH 4 isocr. C18, ACN-HCOOH isocr. Silica, ACN-TFA isocr. Silica, ACN-TFA isocr. C18, ACN-HCOONH 4 isocr. C18, ACN-HCOONH 4 gra

Isolation Sample SPE SPE 96 L/l Plasma, urine SPE SPE SPE SPE SPE SPE 96 SPE 96 SPE SPE SPE SIM = selected ion monitoring, MRM = multiple reaction monitoring, ACN = acetonitrile, TFA = trifluoroacetic acid.

LC/MS Methods Used for Opioids Plasma Plasma Serum, urine Serum, urine Serum Serum Plasma Plasma Plasma Plasma (rat) Plasma Urine

Table 2.1 Drug M, M3G, M6G M, M3G, M6G M, 6-MAM, Cod, NorCod, Pholcod M, M3G, M6G, NorM M, M3G, M6G, 6-MAM, Cod, C6G M, M3G, M6G, 6-MAM, Cod, C6G M, M3G, M6G M, M3G, M6G Fentanyl HYM, HYC HYM, DHM, H3G, other metabolites Buprenorphine, BUG, NBUG Ketobemidone, Nor-K Notes: © 2004 by CRC Press LLC