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M3G
9.0e4
8.0e4 TIC of Injection #4
7.0e4
6.0e4

5.0e4
4.0e4
3.0e4
2.0e4
M6G
1.0e4
Morphine
0.0
0.1 0.2 0.3 0.4
Time, min

M3G
7.0e4
TIC of Injection #376
6.0e4

5.0e4
4.0e4

3.0e4
2.0e4
M6G
1.0e4
Morphine
0.0
0.1 0.2 0.3 0.4
Time, min
Figure 2.3 Total ion chromatograms of injections #4 and #376, both of a mor-
phine/M6G/M3G calibration standard (5:10:100 mg/l) during the continuous anal-
ysis of 384 extracted morphine samples in human plasma. (From Shou W.Z.,
Chen Y.L., Eerkes A., Tang Y.Q., Magis L., Jiang X., and Naidong W., Ultrafast
liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes
using packed silica columns. Rapid Commun. Mass Spectrom. 16, 1613, 2002.
Reproduced by permission of John Wiley & Sons Ltd.)
50
Bogusz et al. determined heroin markers in 25 morphine-positive urine
samples with LC/APCI/MS. Codeine-6-glucuronide was found in all samples,
codeine in 24, noscapine in 22, 6-MAM in 16, papaverine in 14, DAM in 12,
40
and AC in 4 samples. Katagi et al. developed an automatic method for the
determination of heroin and its metabolites monoacetylmorphine (6-MAM)
and morphine, as well as acetylcodeine, codeine, and dihydrocodeine in

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