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107                     W.,              to   The   and   that   on   as   less   of   time   the   The   all   that   time   in

                              D.   Reproduced   detector.   takes   7.4.   should   position   larger   quantitative   based   be   width   seconds.   detectors   of   short-   one’s   Valuable   4.0)   the   found
                              Grant,         a     constants   constants   effects   those   should   0.3   overall   any   the   damping.   improve   record   (not   as   be

                              from  Reprinted   Inc.  Sons,   &   response   of   detector   a   Figure   in  shown   time   four   two  parameters   time   deleterious   (peak   time   get  which   unaffected;   only   while   constant   peak   a   Thus,   of  constant   chromatographic   the   that   for  value   decreasing   called   and   avoided.   be   faithfully   not   time  constants   time   rise   a  define   even   can

                      level  Noise   2.   of   (S/N)   ratio   Copyright   Wiley   John   of   of   speed   the   milliseconds)   or   signal   in   as   response)   takes   these   of   One   increasingly  longer   The  peak.   retention   in  changes   width,   of   both   is  however,   accurate  remain   time   the   that   wy.  height,   half   time   a   to   most   for   Remember   also   limited  largest   the   by   advantage   the   of
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                  L           signal-to-noise   1996.  Wiley,   measure   a   is   (in   time  seconds   change  sudden   full   of   98%   response   time*.   detector.   of  effect   the   chromatographic   a   are   the   peak   on   and   The  increases.   area,   on   will   area   error.   in   [7]   is   at   width   corresponds  mL/min   required  magnitude   data  systems.   is  system   have   do   This  detector.   one’s   the  increasin
    Characteristics           a   of  Illustration   Chromatography,   constant,   7,   the   is   it   of  63.2%   a   (actually   the   as   to   a   for   7.5   shows   of   shape   peaks   chromatogram)   constant   based   will  height   be   recommendation   peak   the   of   flow   1   of   of   order   associated   entire   the   components.   constants   time   a   from   decrease   to   by   lost   be   can   information,   some   90%   (






    Detector                 Fig.   7.3.   Gas  Capillary   permission.   with   Constant  Time   time   The   Specifically,   to  respond   response   full   referred   is   specified   be   Figure   distort   the   chromatographic   the   in   time   the   measurements   peak   on   typical   A   10%   than   a   at   wL   50   This   the   is   their   and   for  constant   individual   Large   noise   term   temptation   chromatograms   informa










    Detectors   from   stray   Circuit   the  isolate   chro-  pure   Society   parallel   lines   the   noise,   long-term   the  possible,   minimized   sugges-   of   lower   limit   signal   that   S/N,   or   seen   be   from   the   be   not   represent       permission.   Inc.,   New




          made,   and  leaks.   can   and   contamination.   American   two   enclose   a  shows   all   or   Some   characteristic   the   smallest   ratio   can   it   peak   a   should   2   and   with   Sons,   &


          are   grounding   pretreatment   the   The   minima   figure   at   If   eliminated   detected.   6.   convenient   about   the   signal-to-noise   7.3;   S/N   of   contamination   Reprinted   Wiley   Inc.

          amplifiers   contamination   and   from   (formerly   Figure   7.2.   and   the   minutes.   and   can   be   reference   a   information   Commonly,   Figure   in   distinguishing   an       ASTM.   Contrasts,   John   Sons,   &




          the   from   shielding   sample   some   noise   ASTM   in   maxima   addition,   30   of   found   be   that  signal   in   is  noise   more   whose   one   shown   for   exceed   from   arise      Time   Copyright   and   Wiley
          which   and   noise;   and   by   depicted   In   period   should   found   the   alone.   is   is   2   value   which   often   instability.      hour      —»   TCD.   Concepts   John   of


         from   some   environment;   eliminate   used  noise   is   peak-to-peak   example.   over   a   drift   minimum   be   can   to  signal   conveys   It   noise   the   analyte   ratio   of   minimum   spikes   these   detector   (mV)   1/2   drift   ina   courtesy
         components   environment,   the   eliminate   from   the   can  gases   of  definition   Materials)  and   the   in   this   occurring   and  noise   the   restrict   the   noise  reducing   the   of   performance.   than   does   attributed   an   to   An   S/N   certainly   a   noise.   Sharp   peaks   as   as   of   type   Noise,   of  noise   and   Chromatography:  M.,   Reproduced





         electronic   in   can   detector   matographic   The   Testing   between   mV   in   drift   or   of   they   for   The   ratio   detection   be   more.   or   this   is   background   interpreted   different   |   Le   Example   J.  Miller,   1987,   93.   p.

   106     signals   design   for   drawn   given   noise   sources   because   tions   detector   of   can   2   is   that   a       7.2.   Fig.   From   York,
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