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264 CHAPTER 10 COMPUTATIONAL BIOLOGY APPROACH ON GENETIC
DISORDER

studied the gene interactions of Alzheimer’s disease, which were analyzed using a string database as
well as finding the binding energy, binding residue, bond name, and bond length of the interactions
between the proteins that are the most targeted with drugs for AD through molecular docking anal-
ysis. From the docking result, it was found that the alpha-synuclein interacted with resveratrol with
GLY36, GLY41, VAL40, and LYS43 residues. They are involved in hydrogen bonds, having bond
˚
˚
lengths of 2.4729A, and a hydrophobic bond length (bond length varied from 3.94828A to
˚
5.05348A). Similarly, the binding energy was 9.6kcal/mol between cyclin-dependent-like kinase
5 and alsterpaullone. ASP86 residue was involvedinthe electrostatic bond with abondlengthof
˚
3.92707A.

ACKNOWLEDGMENTS
S. Sahu and S. Martha are grateful to OUAT Bhubaneswar. M. Moharana expresses her gratitude to the Department
of Science and Technology (DST) Government of India for financial support through grant number SR/WOS-A/
CS-135/2016. S. K. Pattanayak is grateful to the Department of Chemistry, National Institute of
Technology, Raipur.

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