Page 386 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

362 17 Enzymatic Generation of Sialoconjugate Diversity

HO OH HO OH OH HO OH
HO COOH OH
O O HOOC O
HO O O OH OH O O O O O O
OH AcNH O AcHN O OH HO OH
O O O HO OH HO Ceramide
HOOC HO O
OH OH Ceramide AcHN OH
O OH
HO
OH Ganglioside GM 1 Ganglioside GD 3
HO
AcHN OH branched (α2,3) oligomeric (α2,8) (α2,3)
OH
HO COOH
OH OH OH
HO HOOC HO OH O O HO HO
O AcHN O O
O O O O HO
AcHN O HO OH O
OH HO OH AcNH
HO OH OH Ceramide O
Peptide
Sialyl T antigen
Ganglioside GM 3
linear (α2,3) linear (α2,6)
Figure 17.1 Examples of important sialylated oligosaccharide structures illustrating the common linkage types found for natural sialo-
conjugates.