Page 198 - Biodegradable Polyesters

176 7 Electrospun Scaffolds of Biodegradable Polyesters: Manufacturing and Biomedical Application

References [154] [143] [48] [155] [45] [156] [157]

and in the of the that system. crucial vascular within rats increasing defect and complete in regeneration of were
cells implant part vascular the support in the scaffolds condyles zone defect
muscle after inner suggesting the of to able defects scaffolds, across PLGA near bone subchondral

and 1 month the in resilience, in occurs maintenance are calvarial the healing scaffolds the caused the femoral in the osteochondral
endothelial for calcification and as the scaffolds size of bone onto seeded scaffolds accelerated cells defects at bone

of patency response no elasticity loading, and these grafting critical osteoconductivity Smad5 complete composite ASCs/PLGA cells without and 5 mm a
growth and and cyclic strength that after in and almost the were of scaffolds osteochondral surface repair

the integrity inflammatory vivo high repeated and suggest period regeneration the BMP-2 of (ASCs) The presence in could
support shown in vivo exhibited modulus also improves showed implantation cells defects. The implanted implanted articular scaffolds

to able structural abnormal was in observed fibers withstand of resilience remodeling bone favor BMP-2 osteocalcin, model after stromal tibial defects. PLGA were the at PLGA
Scaffolds properties were Scaffolds their maintained without rabbits Biocompatibility was scaffold copolymer The could scaffolds loss gradual The and elasticity the during tissue scaffolds The The 8 weeks. of expression defect cranial Rat 12 weeks area, Adipose-derived rat in implanted tibial in healing to comparison scaffolds
Examples of electrospun polyesters used in tissue engineering.

for VEGF and DBPs
blend graft and with PLLA nanosized

Polymer system PCL–collagen PCL–heparin electrospinning posttreatment Poly(trimethylene carbonate-co-L-lactide) (PTMCLAA) of Emulsion BMP-2 of Blend PLA and PLGA PLGA

for
scaffold tissue regeneration properties grafts

Table 7.2 Application Tubular vascular engineering Bone Scaffolds Cartilage