Page 199 - Biodegradable Polyesters

7.4 Applications 177

[40] [158] [47] [159] [160]

the their at and the and
of relation at the spinal that with greater
range scaffolds suggesting number in modify animal supports at significantly elongation, showed electrophysiological fibers scaffolds were regeneration

the fibrosis can In hemisection graft material
in the addition, lineage, differentiation macrophage scaffolds vitro. in scaffold the were adhesion, rats, adult the addition, rate PCL scaffolds nerve
(53.67 ± 3.48 MPa), In epidermal regional and epidural reduced PLCL that cells nerve lateral complete the that enter to seen animals grafted cell in gap nerve similar achieving In autografts. regeneration with compared p-PCL (p-PCL). cost-effective a is peripheral for

modulus (15–150 MPa). the along without The nanofibers were applied in animal models of spinal cord injury. The animals that proliferation more a indicate limit the scar formation and epidural fibrosis in spinal cord, preventing cicatrization of growth the with rats demonstrated were axons of scores Schwann the sciatic regeneration, as such

elastic skin human MSCs of regeneration fibroblast less exhibited results initial support to applied findings regenerating sensory vitro in 8 mm with results, matched well plasma p-PCL scaffolds,

showed native differentiation skin in showed animals The to able were Histological and and group sustained tests, nerve which collagen/PCL by the on PCL/collagen

scaffolds of modulus the application scaffolds These site. group. were scaffolds level. regeneration Locomotor control the fibers vivo In supported re-enervation degraded, with made modified morphology to

Coll/PLCL elastic supported potential received injury the control the to scaffolds The the models, T9–T10 axonal sites. injury than better Collagen/PCL proliferation. scaffolds the muscle and gradually Scaffolds surface their normal compared

and blend
collagen (70 : 30) collagen/PCL BMP-2, bone morphogenetic protein 2 and DBPs, demineralized bone powders.

of poly(L-lactide-co- caprolactone) (Coll/PLACL) Collagen/PCL and
Blend PLACL PLGA PCL blend

regeneration cord nerve

Skin Spinal regeneration Peripheral grafts