Page 197 - Biomedical Engineering and Design Handbook Volume 2, Applications

176 MEDICAL DEVICE DESIGN

TABLE 6.2 Examples of Various Marketed Controlled-Release Drug Delivery Products
Product Route of Developer/
Design Principle Name Active Ingredient Administration Manufacturer
Diffusion (reservior) Estraderm Estradiol Transdermal Alza/Novartis
Norplant Levonorgestrel Subdermal Wyeth-Ayerst
implant Laboratory
Ocusert Pilocarpine Ocular Alza
Progestasert Progesterone Intrauterine Alza
Transderm Scop Scopolamine Transdermal Alza/Novartis
Diffusion (matrix) Nitro-Dur Nitroglycerine Transdermal Key Pharmaceutical
Nitrodisc Nitroglycerine Transdermal Searle
Mixed (matrix- Catapress-TTS Clonidine Transdermal Alza/Boehinger
reservoir) Ingelheim
Oxytrol Oxybutynin Transdermal Watson
Duragesic Fentanyl Transdermal J&J (Ortho McNeil
Janssen)
Deponit Nitroglycerine Transdermal Pharma-Schwarz
Porous matrix K-Tab Potassium chloride Oral tablet Abbot Labs.
Hydrodynamically Medopar DR Levodopa and Oral tablet Roche
balanced system benserazide
Glucophage XR Metformin Oral tablet Bristol Myer
Squibb
Xatral OD Alfuzosin Oral tablet Skye Pharma
Valrelease Diazepam Oral tablet Roche
Ion-exchange Colestid Colestipol Oral tablet Upjohn
or granules
Questran Cholestyramine Oral tablet Bristol Labs
or powder
Tussionex Chlorpheniramine Oral suspension Fisons
Pennkinetic and hydrocodone
Nanocrystal Rapamune Sirolimus Oral tablet Elan/Wyeth-Ayerst
technology Laboratory
Coating Compazine Prochlorperazine Oral capsules Glaxo Smith Kline
Spansule
Verelam PM Verapamil Oral capsules Schwarz Pharma/
Elan
Innopran XL Propranolol Oral capsules Reliant
Dexedrine CR Dextroamphetamine Oral capsules Glaxo Smith Kline
Fefol-Vit Ferrous sulfate Oral capsules Glaxo Smith Kline
and vitamins
Ecotrin Aspirin Oral tablet Glaxo Smith Kline
Voltaren Diclofenac Oral tablet Geigy
Eskalith CR Lithium carbonate Oral tablet Glaxo Smith Kline
®
Adalat CC Nifedipine Oral tablet Bayer
Ery-Tab ® Erythromycin Oral tablet Abbot
®
Focalin XR Dexmethylphenidate Oral tablet Novartis
Lialda TM 5-Aminosalicylic Oral tablet Shire
acid
Sular ® Nisoldipine Oral tablet Sciele Pharma/
Bayer
Coreg TM CR Carvedilol Oral tablet Glaxo Smith Kline
(Continued)