Page 199 - Biomedical Engineering and Design Handbook Volume 2, Applications

178 MEDICAL DEVICE DESIGN

TABLE 6.2 Examples of Various Marketed Controlled-Release Drug Delivery Products (Continued)
Product Route of Developer/
Design Principle Name Active Ingredient Administration Manufacturer
Thermally ThermoDox Doxorubicin Parenteral Celsion
triggered release
Pegylated systems Macugen Pegaptanib sodium Parenteral Pfizer/OSI
Oncaspar PEG−L-asparginase L-asparginase Enzon
Adagen PEG−Adenosine Parenteral Enzon
Deaminase
PEGIntron PEG−Interferon α2b Parenteral Schering Plough
PEGASYS PEG−Interferon α2a Parenteral Roche
Neulasta Pegfilgastrim Parenteral Amgen
Ligand-based Herceptin Trastuzumab Parenteral Genentech
targeted delivery Avastin Bevacizumab Parenteral Genentech
Rituxan Rituximab Parenteral Genentech/Biogen
Idec
Raptiva Efalizumab Parenteral Genentech
Xolair Omalizumab Parenteral (sc) Genentech/Novartis
Remicade IgG1κ (anti-TNFα) Parenteral Centocor
Bexxar Tositumomab Parenteral Glaxo Smith Kline
Tysabri Natalizumab Parenteral Biogen Idec/Elan
Soliris Eculizumab Parenteral Alexion
Programmable drug Animas 2020 Insulin Parenteral J&J (Animas Corp.)
delivery systems MiniMed Paradigm Insulin Parenteral Medtronic
REAL-Time
CozMore Insulin Parenteral Smiths Medical MD
Insulin pump
system
Accu-Chek Spirit Insulin Parenteral Roche
OmniPod Insulin Parenteral Insulet Corp.
Amigo Nipro Insulin Parenteral Nipro Diabetes
Systems

REFERENCES

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