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38 2 New Trends in the In Situ Enzymatic Recycling of NAD(P)(H) Cofactors

systems to be used in ADH-catalyzed oxidations. Already established methods,
such as the pyruvate/LDH system, are sufficiently efficient and robust for industrial
applications, but the cost of the co-substrate can render them not yet sufficiently
competitive to traditional chemical oxidation methods. However, it can been
foreseen that the exploitation of O -based biocatalysts, such as NADH oxidases
2
and laccases (via redox mediator), will further boost the application of NAD(P)H-
dependent dehydrogenases toward the foreseeable development of selective and
green catalytic oxidation methods.

Acknowledgments

The authors thank the ESF project COST CM0701 for support.

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