Page 154 - Color Atlas of Biochemistry

Energy Metabolism 145

A. Respiratory control

AH 2 A 1 3 AH 2 A

Coupling
1 1
points
N A Dehydro- N A N A Dehydro- N A
genases genases

2 2

H Respira- H H H
outside tory chain inside ATP syn- outside inside
thesis
uncoupled Heat
3 from proton
transport
3
A P ATP A
P P synthase P P P A P A
P P P P P
Endergonic
processes Endergonic
processes

1. Coupled 2. Uncoupled

B. Uncouplers C. Regulation of the
tricarboxylic acid cycle
1. Membrane Insulin Pyruvate
1. damage H H

1a 1b Ca 2
H

O NO 2 NADH
NO 2
2. Mobile Acetyl CoA
2. carriers
O N
2 2
NO 2 OH
2,4-Dinitrophenol Oxalo- Citrate
acetate
H
Inner
mitochochondrial Most important Isocitrate
membrane factor: con- N A
centration ratio
[NADH] / [NAD ] NADH
3
Norepinephrine

2-Oxo-
Succinyl glutarate
Fatty CoA 4
Fat acids H Ca 2

PDH kinase Isocitrate dehydro-
1a 3
H 2.7.1.99 genase 1.1.1.42
Thermo-
genin PDH phosphatase 2-Oxoglutarate
3. Gated proton (UCP1) 1b 3.1.3.43 dehydrogenase 1.2.4.2,
3. channels 4 1.8.1.4,2.3.1.61
Citrate synthase
2
4.1.3.7

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
All rights reserved. Usage subject to terms and conditions of license.