Page 156 - Color Atlas of Biochemistry

Energy Metabolism 147

A. Aerobic and anaerobic oxidation of glucose

Glucose 1 2 Glucose 1 2
A A A A
Glyco- P P P P P P P P P P P P
lysis
2 PEP 4 3 2 PEP 4 3
P A P
A
2 2
P P P P
5 2 N A 2 N A 5 2 N A 2 N A
2 A 2 A
P P P P P P
2 Pyruvate 2 Pyruvate 6
2 Lactate
Malate shuttle

Pyruvate Pyruvate

7
7

Acetyl Acetyl N A
N A N A N A
CoA CoA
Tricarboxylic
H acid cycle H
8 inhibited due 8
to high ratio of
9 9
NADH/NAD
10 H 10 H
11 11
12 12
O 2 H O 2 H
2 GTP
H O
2
A A P A A P
P P P P P P P P P P

1. Aerobic 2. Anaerobic

ATP Coenzymes Enzymes Coenzymes ATP

–1 –1 ATP 1 Hexokinase –1 ATP –1
–2 –1 ATP 2 6-Phosphofructokinase –1 ATP –2
+3 +5 ATP +2 NADH 3 Glyceraldehyde-3 DH +2 NADH –2
P
+5 +2 ATP 4 Phosphoglycerate kinase +2 ATP NAD 0
+7 +2 ATP 5 Pyruvate kinase +2 ATP recycled +2
6 Lactate dehydrogenase –2 NADH
+12 +5 ATP +2 NADH 7 Pyruvate dehydrogenase
+17 +5 ATP +2 NADH 8 Isocitrate dehydrogenase
+22 +5 ATP +2 NADH 9 Oxoglutarate dehydrogenase
+27 +5 ATP +2 NADH 10 Malate dehydrogenase
+30 +3 ATP +2 QH 11 Succinate dehydrogenase
2
+32 +2 ATP +2 GTP 12 Succinate-CoA ligase

DH = dehydrogenase
Sum: 32 ATP/glucose Sum: 2 ATP/glucose

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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