Page 150 - Color Atlas of Biochemistry

Energy Metabolism 141

A. Components of the respiratory chain

Pyruvate Liponamide-H 2 E OI Complex I
2-Oxoglutarate HS SH (V
H NADH dehydrogenase (ubiquinone)
1.6.5.3
M r 700 - 800 kDa, 25 - 30 subunits
I -0.3
1 FMN, 2 Fe S , 4 - 5 Fe S
2 2
4 4
Succinate
3-Hydroxybutyrate Complex II
3-Hydroxyacyl CoA N A Succinate dehydrogenase 1.3.5.1
Malate
Isocitrate NADH M r 125 kDa, 4 - 6 subunits
Q II +0.1 1 FAD, 1 Fe S , 1 Fe S , 1Fe S
2 2
4 4
3 4
2 ubiquinone, 1 heme b
Complex III
H
Fumarate Ubiquinol-cytochrome C
Acyl CoA III reductase 1.10.2.2
α-Glycerophosphate ETF M r ≈ 400 kDa, 11 subunits
Dihydroorotat
Cholin 2 Fe S , 2 heme b, 1 heme c 1
2 2
Complex IV
Cytochrome C
M r 12 kDa Cytochrome C oxidase 1.9.3.1
nH 1 heme
+0.3 M r ≈ 200 kDa, 8 - 13 subunits
2 Cu, 1 Zn, 1 heme a, 1 heme a 3
V
H
Complex V
CN
IV CO H -transporting ATP synthase
A A 3.6.1.34
P P P nH PP P
M r >400 kDa, >20 subunits
O 2
2 H
1/2 O 2 Electron flow
+0.8 Proton flow
H O
2
B. Organization

Outer
mitochon-
drial
membrane
Inter-
membrane
4 H 4 H 2 H space
II
Inner
I Cyto- ? mitochon-
Q chrome C ∆p drial
III IV V membrane

2 e 4 H 2-4 H

4 H 1/2 O 2 2 3 P Matrix
2 H O space
N A N A 3 A 3 A
P P PP P
ATP
Tricarboxylic NAD H O 10 H
NADH+H acid cycle 2
β-Oxidation

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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