Page 146 - Color Atlas of Biochemistry

Energy Metabolism 137

A. Tricarboxylic acid cycle

Center of chirality COO
Acetyl CoA
H C OH
7 H C H 8 +28.1
H 2O S C CH 3
-3.8 COO A
O
COO ∆G 0I (2S) - Malate
kJ · mol -1 COO
H C
C O
C H N A N A
CH 2
COO
COO
Fumarate Oxaloacetate
OH Ubiquinol
QH 2 H 2O
6 ±0 1 -38.2

OH S
O A
Respiratory OOC COO
COO
chain
2
CH O H C C OH
2
CH 2
CH 2
COO
COO
Citrate
Succinate
G
PP P
5 -8.8 GTP N A N A 2 +6.7

G N A N A
P P OOC
OOC COO
P H C CH 2
2
H C
2 C H
S C O
A H C OH
COO
Succinyl CoA
S OOC (2R,3S)-Isocitrate
A -37.0 -7.1
H C CH 2
2
4 3
C O
O C O CO 2 O C O CO 2
COO
2-Oxoglutarate

Citrate synthase 2-Oxoglutarate DH complex Succinate DH 1.3.5.1
1 4.1.3.7 4 1.2.4.2, 1.8.1.4, 2.3.1.61 6 [FAD, Fe S , Fe S ]
4 4
2 2
2 Aconitase 5 Succinate-CoA ligase 7 Fumarate hydratase
4.2.1.3 [Fe S ] 6.2.1.4 4.2.1.2
4 4
3 Isocitrate DH 1.1.1.41 DH = dehydrogenase 8 Malate DH 1.1.1.37

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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