Page 148 - Color Atlas of Biochemistry

Energy Metabolism 139

A. Tricarboxylic acid cycle: functions

* Essential Asp, Asn, Glucose
* amino acid Arg, Met*, GTP
Thr*, Ile*

Fat Oxaloacetate 3 PEP Phe*, Tyr, Trp*
2 Irreversible Ala, Ser, Thr*,
Cys, Gly
Acyl- Malate Ala, Leu*, Pyruvate Carbo-
CoA Val* hydrates
CO
Cytoplasm 2
N A
P
Carnitine 5
shuttle CO 2 Pyruvate N A
P
ATP Irreversible
CO 2 Malate 2 Oxalo-
acetate
Acyl Acetyl
CoA CoA

β-Oxidation
1

Mitochondrial Malate 2 ATP ADP+P
matrix i
Oxalo-
acetate
Citrate 4
Fumarate
Asp Asp
Phe* Asn Citrate S
Tyr A
His CoA
Ile* Pro Acetyl
CoA
Succinate Val* Arg
Met* Gln
Trp* Glu
Isocitrate
Fatty
GTP acids
Succinyl
CoA 2-Oxo- CO
glutarate 2
Fat
CO 2
Glu, Gln,
Porphyrins
Pro, Arg Pyruvate carboxylase
1
6.4.1.1
OH 2 Malate dehydrogenase
1.1.1.37
NADH+H N A 2[H] O 2 2[H] Ubiquinol PEP carboxykinase
(QH ) 3 4.1.1.32
2
OH
4 Citrate lyase 4.1.3.8
A Oxidative A
P P + P phosphorylation P P P 5 Malic enzyme 1.1.1.40
ADP P i ATP Catabolic pathway
H O Anabolic pathway
2
Anaplerotic reaction

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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