Page 144 - Color Atlas of Biochemistry
P. 144
Energy Metabolism 135
A. Pyruvate dehydrogenase: reactions
E1
CO 2 R
OH
Pyruvate H 3 C N C C CH Hydroxyalkyl thiamine
O 3 diphosphate
S H
OOC C CH 3 R
1
E2
2
O
Acetyl
R 1 S S S CCH 3 lipoamide
N S
H 3 C H
H
S S
R 2 A
Thiamine 3 CoA
diphosphate
TPP
O
S S CCH 3
A
S S
H S
Acetyl CoA
E3 4a H
Dihydrolipoamide
F A F A
Pyruvate dehydro- 4b
E1 genase 1.2.4.1
E2 Dihydrolipoamide
acetyltransferase 2.3.1.12 N A N A
E3 Dihydrolipoamide
dehydrogenase 1.8.1.4 NAD NADH + H
B. PDH complex of Escherichia coli
10nm
E1 12·2=24 E1 E3
E2 8·3=24 E2
E3 6·2=12
E1+ E2+E3=60
1. 2.
Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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