Page 176 - Color Atlas of Biochemistry

Lipid Metabolism 167

A. Degradation of unsaturated fatty acids

Linoleoyl CoA (18 : 2; 9,12)
O
9
C S 1 2
A
Shift and Reduction and
12 izomerization shift of the
cis 3 CoA of the marked
marked double bonds
double bond
β-Oxidation

3 Acetyl CoA

O O O
3
C S 2 C S 2 C S
A A A
6 trans 4 trans
cis β-Oxidation
1 6 cis

cis
CoA Acetyl CoA
NADPH

N A
O O P
2
S
2 C S C
4 CoA A A N A
3 P
trans trans
1 NADP

β-Oxidation

Enoyl-CoA isomerase
1
5 Acetyl CoA 5.3.3.8
2,4-Dienoyl-CoA reductase
2
1.3.1.34

B. Degradation of odd-numbered fatty acids

Propionyl-CoA carboxylase
Odd-numbered 3
fatty acids 6.4.1.3 [biotin]
Methylmalonyl-CoA mutase
4
H O β-Oxidation 5.4.99.2 [cobamide]
H C C S
A A A Tricarboxylic acid cycle
PP P P P
H
n Acetyl CoA P
H H O H H O O H H

H C C C S 3 H C C C S 4 S C C C H
A A A
H H S A H COO H COO

Propionyl CoA CO 2 Methylmalonyl CoA Succinyl CoA

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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