Page 172 - Color Atlas of Biochemistry

Lipid Metabolism 163

A. Fat metabolism

1 Lipoprotein 5 Acetyl-CoA
lipase 3.1.1.34 carboxylase
Epinephrine Largest 6.4.1.2 [Biotin]
2 Hormone-sensitive Norepinephrine Adipocyte energy
lipase 3.1.1.3 Glucagon etc. store 6 Fatty acid
synthase
3 Fatty acid-CoA 2.3.1.85
ligase 6.2.1.3 Triacylglycerols
Carnitine O- Insulin
4 palmitoyltrans- 2 COO
ferase 2.3.1.21
Free fatty acids From the
intestine

1 Insulin
COO
Chylo-
Fatty acid-albumin complex microns

Blood
VLDL
Hepatocyte
Free fatty acids

CoA ATP
3 Triacylglycerols
AMP+ PP

Acyl CoA Fat biosynthesis

Mitochondrion 4
Acyl CoA

Acyl CoA Unsaturated Elongated
fatty acids fatty acids

NADH β-Oxidation Palmitate
+H
NADP CO 2
7x 6
Acetyl CoA
Acetyl CoA NADPH or acyl CoA
+H
Malonyl CoA
ADP+ P
Ketone bodies Citrate
Insulin
5
Glucagon
ATP HCO 3
Citric acid
cycle Acetyl CoA
Respiratory
chain
Amino acid Glycolysis
Supply degradation
of energy
to other
tissues CO +ATP Amino acids Glucose
2

Most important
Fatty acid Fatty acid precursor
degradation biosynthesis

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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