Page 174 - Color Atlas of Biochemistry

Lipid Metabolism 165

A. Fatty acid degradation: β-oxidation

Electron-
transferring F A QH 2
flavoprotein (ETF)
Respiratory
5 chain
β-Carbon F A
H H H O 1 Q
C C C C S H O
A
H H H C C S
Acyl CoA A
H
Acyl CoA
S 4 (n – 2 carbons)
A H O
H C C S
A
H O H
H C C S
H O H O H A
H C C S
H O H O H C C S H H O H A
A
C C C C S H C C C C S
A Acetyl CoA A
H H H H

H O
2
N A Tricarboxylic acid cycle 2
3
1 Acyl-CoA dehydrogenase 1.3.99.3
H OH H O
2 Enoyl-CoA hydratase 4.2.1.17
Respiratory N A C C C C S
chain A 3 3-Hydroxyacyl-CoA dehydrogenase
H H H 1.1.1.35
4 Acetyl-CoA acyltransferase 2.3.1.16

5 ETF dehydrogenase [FAD, Fe S ] 1.5.5.1
4 4

B. Fatty acid transport

Carnitine O
1 Acyl
O-palmitoyltransferase C carnitine
2.3.1.21
O CH 3
Fat degradation β-Oxidation
OOC CH 2 C CH 2 N CH 3

H CH 3

S Acyl Acyl S
A A
Carnitine Carnitine
1 1

S S
A Acyl Acyl
carnitine carnitine A
A

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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