Page 178 - Color Atlas of Biochemistry

Lipid Metabolism 169

A. Fatty acid synthase B. Reactions of fatty acid synthesis

1 2 Substrate entry 5 Water cleavage 1 7 Palmitate
3 Chain elongation 6 Reduction
H2O Product
4 Reduction 7 Product release release
O H H H

Pan–S C C C C H Acyl-
Palmitate Cys–SH H H H
1 st domain 6 5 6 N A P NADP

1
2
4
N A
7 NADP+H
P -Pantethein ACP P
3 O H H
Cys SH SH
SH SH Cys Pan–S C C C C H trans-Enoyl-
3
ACP Cys–SH H H
7
4 2 1 H O
2
5
3 rd 6 5

domain 2
nd
O H OH H
domain
Pan–S C C C C H 3-Hydroxy-
Acetyl S acyl-
A
Cys–SH H H H
Malonyl S N A
A NADP
P
4
N A
P NADP+H
1 [ACP]-S-Acetyl-
transferase 2.3.1.38
O H O H
2 [ACP]-S-Malonyl- Pan–S C C C C H 3-Oxoacyl-
transferase 2.3.1.39
Cys–SH H H
3 3-Oxoacyl-[ACP] 7x
synthase 2.3.1.41
CO 2
3
4 3-Oxoacyl-[ACP]
reductase 1.1.1.100 H
O H
5 3-Hydroxypalmitoyl-[ACP]
dehydratase 4.2.1.61 Pan–S C C COO
H
6 Enoyl-[ACP]
reductase (NADPH) 1.3.1.10
O H
S
7 Acyl-[ACP] S Cys–S C C H A
hydrolase 3.1.2.14 A
H 2
1

Acetyl or Malonyl S
Starting reaction Acetyl S acyl residue
A A

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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