Page 222 - Color Atlas of Biochemistry

Mitochondria 213

A. Transport systems
Driving force: ATP 4 2-Oxoglutarate/citrate
Membrane 3
potential ADP –
Proton 2-oxo- Malate
gradient glutarate/
citrate A
A
H 2PO 4 4
H 2O ATP – HPO 4 2
Malate
3
ADP
A
Citrate export
OH H 2PO 4 Malate shuttle
A HPO 4 2
H + U
OH ATP synthesis
Ca 2 +
Pyruvate A Ca 2 +
Ca 2 + storage H +
Pyruvate Breakdown Ca 2 + release +
Conversion A (Na )
Inner mitochondrial membrane

B. Malate and glycerophosphate shuttle

1 Glyceraldehyde 2a 2b Malate dehydrogenase 1.1.1.37 4 Glycerol 3-phosphate dehydrogenase 1.1.1.8
3-phosphate
dehydrogenase 3a 3b Aspartate transaminase 2.6.1.1 5 Glyceral 3-phosphate DH (FAD) 1.1.99.5
1.2.1.12
Glucose 6-
NADH + H + phosphate
Cyto- Cytoplasma 1,3-Bisphos- Glyco-
phoglycerate
plasm lysis
Glu Oxalo- N A Fructose 1,6-
acetate 1 bisphosphate
3b 2a

Glyceral 3- Glycerone 3-
N A phosphate phosphate
Asp 2-Oxo-
glutarate Malate
4
Outer
Glycerophos- Glycerol 3-
phate shuttle phosphate
Mitochon- Malate
drial
membrane shuttle Porin
Complex I
Ubiquinone
Inner I

2-Oxo- Malate
Asp Q
glutarate N A
5
3a 2b
Complex III
Oxalo-
Glu N A
acetate
Complex IV
+
Matrix NADH + H + 2H , O
Mitochondrion
H O
2

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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