Page 254 - Color Atlas of Biochemistry

Transcriptional control 245

A. Initiation of transcription
Enhancer Histone deacetylase Activator Regulator Coactivator complex
(HRE) protein protein (histone acetylase)
1
2
TATA-Box TATA box

Histone “tails”

Nucleosome Upstream promoter element
Coactivator complex
Mediator complex 1 Histone deacetylase n.n.n.n
2 TAFs 2 Histone acetyltransferase 2.3.1.48
RNA polymerase II 3 RNA polymerase 2.7.7.6
4 DNA topoisomerase I 5.99.1.2
D F 3 HRE – hormone response element
A TAFs – TBP-associated factors
TBP B E H 4 TBP – TATA box-binding protein
A–H – basal transcription factors
Basal transcription complex

B. Regulation of PEP-CK transcription
Control AF-1 IRE GRE TRE P4 CRE P1 CRE TATA-Box
element

Transcription
factor RAR ? GR TR AP-1 C/EBP HNF-1 NF-1 C/EBP TBP Tran-
(Fos/Jun) CREB scription
start
Receptors for retinoate
cortisol thyroxine

Insulin
PI 3K

Coactivator
Mediator
(CBP/p300)
Cortisol GR GRE

NF-1
Thyroxin
TR TRE
C/EBP
P1
CRE TATA box
cAMP
Glucagon Basal transcription complex
PK-A C/EBP

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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