Page 312 - Color Atlas of Biochemistry

Immune response 303

A. Variability of immunoglobulins
Constant Variable
domain domain

κ or λ Hyper-
variable
regions
α,δ,ε,γ
or µ Constant
domain

Isotypic Allotypic Idiotypic

B. Origins of antibody variety C. Biosynthesis of a light chain

J
J
J
V 1 V 2 V 3 V 4 V 5 V 6 V .... L V 1 L V 2 L V 3 L V n J 1 2 3 4 C
DNA Intro Is removed Germ
line
DNA
V/J Recombination
Protein

1. Multiple genes

J
V J 1 J 2 J 3 J 4 L V 1 L V 2 L V 3 2 3 C
J
Germ line B cell
Point mutations DNA DNA
during B cell
maturation
Somatic
DNA Transcription
in B cell
L V 3 J 2 3 C
J
AAA....
Protein
hnRNA
2. Somatic recombination
Splicing

Germ line
DNA
Selection and L V J C
linkage of 3 2
gene segments
Somatic AAA....
DNA
mRNA
Translation

V 3
Protein H N J 2
3
C
Protein
3. Somatic mutation COO

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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