Page 308 - Color Atlas of Biochemistry
P. 308
Immune response 299
A. Complement activation
Pathogen surface
Immune complex
Lipopolysaccharide
C4 C2 B
C1 C2b
D
C4b C2a Bb
Classic pathway C3 convertase Alternative pathway
C2aC4b C3bBb
1
Is Collagen- C3
activated like
when filament S C O
C1q C3 C3b
binds 1
to Ab
C3a
C3a
C1r*
and C3b
C1s*
S C
H O O NH 2
2
Chemo- Opson-
Affinity C1q taxis ization
for C3b’
antibody
Fc domain SH C
NH O
Bacterium
Membrane
1 C3/C5 convertase attack
3.4.21.43/47
C6 C7 C8 C9
C5
2
C5b
Bacterial membrane
Membrane
attack complex
2 C5 convertase 3.4.21.47 C2aC3bC4b or (C3b) 2 Bb
Structure of the membrane attack complex
Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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