Page 310 - Color Atlas of Biochemistry

Immune response 301

A. Domain structure of immunoglobulin G

Antigen- Heavy
binding chain
site “Hinge” region
(450 AA)
Variable V H
domain Light
chain
S S
H
S S C 1 S S (212 AA)
F fragment S S
ab
V
S S L
S S S S
S S S S
S S
S S C L F
S S ab
Oligo- Cleavage site
saccharide S S for papain
S S C 2 3.4.22.2
H
Light chain Oligo- F
saccharide c
Disulfide S S
bond S S C 3
H
F c fragment C-terminal end

Heavy chain

B. Classes of immunoglobulins

IgA IgD IgE IgG IgM
360-720 kDa 172 kDa 196 kDa 150 kDa 935 kDa

S S S S

S S S J
J S S S S S S
S S S S S
S S
IgA IgG
3.5 13.5 IgM
IgD IgE
0.03 0.00005 1.5
-1
Serum concentration (g · l )
Chain:
H α δ ε γ µ

L κ or λ κ or λ κ or λ κ or λ κ or λ
Structure:
(α κ ) J δ κ ε κ γ κ (µ κ ) J
2 2 5
2 2
2 2
2 2
2 2 n
(α λ ) J δ λ ε λ γ λ (µ λ ) J
2 2 5
2 2
2 2
2 2
2 2 n
n =1, 2 or 3
Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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