Page 322 - Color Atlas of Biochemistry

Liver 313

A. Lipid metabolism

Intestine Adipose tissue Muscle

Glucose Fatty acids

Acetyl CoA Ketone bodies Ketone
bodies

Apolipo-
Fats proteins

Fats Fatty acids Phospholipids VLDL
Cholesterol

Cholesterol
Chylomicron
residues
HDL
Cholesterol Bile IDL
esters acids LDL

Bile Peripheral
tissues
Absorptive state
Postabsorptive state
A. Biosynthesis of ketone bodies

H O H O H O H OH H O
3 1
H C C S H C C C C S H C C C C S
A A A
H H H H H
H C H
COO
3-Hydroxy-
Acetyl CoA 1 Acetacetyl CoA 2 3-methyl-
glutaryl CoA
Acetyl CoA CoA Acetyl CoA CoA

3

+
H OH H H O H H H O H
3 1
H C C C COO H C C C COO H C C C H
H H H H H H H
3-Hydroxybutyrate 4 Acetacetate 5 Acetone

N A N A CO 2

1 Acetyl-CoA-C-acyltransferase 2.3.1.16 3 Hydroxymethylglutaryl-CoA lyase 4.1.3.4
2 Hydroxymethylglutaryl-CoA synthase 4.1.3.5 4 3-Hydroxybutyrate dehydrogenase 1.1.1.30

5 Nonenzymatic reaction

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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