Page 324 - Color Atlas of Biochemistry

Liver 315

A. Bile acids and bile salts

Cholesterol Bile acids HO– in position

Primary bile acids
— Cholic acid C-3 C-7 C-12
— Chenodeoxycholic C-3 C-7 -
acid

Secondary bile acids
— Deoxycholic acid C-3 - C-12
— Lithocholic acid
C D C-3 - -
A B
3 Bile salts
HO
O
C
14 steps OH N COO
H

Cholic acid COO Glycine
OH
Glycocholic acid
HO OH
12
C D
O
A B
3 7 OH C SO 3
HO OH N
H
Taurine
Taurocholic acid

HO OH

Bile salts = conjugated bile acids

B. Metabolism of bile salts

R
1
Primary Cholesterol
bile acids Intestine
2 Glycine, taurine

Bile salts 15 – 30 g
3
Gallbladder Bile
Bile salts

Breakdown of bile salts Glycine,
by intestinal bacteria 4 taurine

Secondary Primary
bile acids bile acids
5

Resorption 6
Enterohepatic
circulation

0,5 g Feces

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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