Page 330 - Color Atlas of Biochemistry

Liver 321

A. Blood ethanol level
Vol.% Blood alcohol level
[‰]
Whiskey
Cognac
40 1,0
Corn liquor Maximum after 60 – 90 min
Constant decline
30 Cherry brandy ca. 0.015 % · h -1

0,5
Rapid increase
Advocaat 20 due to easy
resorption
Red wine
10
White wine Strong beer
0,0
Beer 1 2 3 4 5 6 [h]
Water Vodka (55 Vol.%) 0.75 g EtOH · kg -1

B. Ethanol metabolism
Accumulates

N A N A N A N A

H H H H O H O
H C C O 1 H C C 2 H C C
H H H H H O
Ethanol Ethanal Acetate
A
PP P
O 2 2 H O
2
S
‚MEOS‘ A
[Cyt P-450] 3
A
P
N A N A P P
P P H O

1 Alcohol dehydrogenase 1.1.1.1 [Zn 2 ] Fatty acid H C C S A
and H
2 Aldehyde dehydrogenase 1.2.1.3 cholesterol Tricarboxylic
biosynthesis acid cycle Acetyl CoA
3 Acetate-CoA ligase 6.2.1.1

C. Liver damage due to alcohol

> 50–60 g EtOH > 160 g EtOH
daily daily
Healthy Fatty Cirrhotic
liver liver liver

Abstinence Death

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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