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Kidney      323


                 A. Functions of the kidneys


                  1. Excretion                                                3. Hormone synthesis



                 Water
                 Salts
                 Metabolic
                 wastes                                                                      Erythropoietin
                 Foreign                                                        V     H      Calcitriol
                 substances



                                                                              4. Metabolism

                                                                                     Glucose          Blood
                   2. Homeostasis

                 Acid-base balance                                                          Gluconeo-
                 Electrolyte balance                                         Amino          genesis
                                                                             acids






                                                                                     NH 3             Urine


                 B. Urine formation
                                                                                                Distal
                                                                          Resorption            tubule
                 Afferent              Glomerulus
                 arteriole                                  Proximal
                                                            tubule                              Regulated
                                                                                                secretion




                                                     Ultra-
                                                     filtration

                                             Final
                                             urine                                              Collecting
                                                              Secretion                         duct
                 Efferent              Bowman’s
                 arteriole             capsule
                  Renal corpuscle
                                                                   Henle’s
                                                                   loop
                  Ultrafiltration   Secretion     Resorption
                                                                                                Regulated
                                                                                                resorption
                 All solute        H             Glucose
                 plasma            K
                 components                      Lactate
                 smaller           Drugs         2-Oxoacids                                     of H O
                 than                            Amino acids                                        2
                 3 nm = 15 kDa     Uric acid
                                   Creatinine    Na   , K   , Ca 2    , Mg 2
                                                        2      2
                                                 Cl   , SO 4  , HPO 4,  HCO 3
                                                 Water, etc.






           Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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